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What drugs cause aphasia?

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Aphasia is a language disorder that affects a person’s ability to communicate. It is typically caused by damage to the parts of the brain that are responsible for language, most commonly from a stroke, but can also be from head injury, a brain tumor, or an infection.

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Interestingly, there are certain medications that have been reported to cause aphasia. These include:

Aphasia/ Image Credits: The Aphasia Center

Ipilimumab: This is a type of cancer medication that is used to treat melanoma (a type of skin cancer). It works by helping the body’s immune system fight cancer cells.

Immunomodulatory drugs: These are drugs that modify the immune system. Examples include thalidomide, lenalidomide, and pomalidomide. They are often used to treat conditions like multiple myeloma and certain skin and nerve disorders.

Lamotrigine: This is a type of medication that is used primarily to treat epilepsy and bipolar disorder. It works by stabilizing electrical activity in the brain.

Vigabatrin: This is an anti-epileptic medication. It is used to treat seizures in individuals with epilepsy.

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Sulfasalazine: This medication is used to treat rheumatoid arthritis, ulcerative colitis, and Crohn’s disease. It works by reducing inflammation in the body.

Cyclosporine A: This is a medication that is used to prevent organ rejection in people who have received a liver, kidney, or heart transplant. It is also used to treat severe rheumatoid arthritis and psoriasis.

Ifosfamide: This is a type of chemotherapy drug that is used to treat various types of cancer. It works by slowing or stopping the growth of cancer cells.

Phenylpropanolamine: This is a medication that was previously used in many over-the-counter and prescription cough and cold medications.

Naftidrofuryl oxalate: This is a medication that is used to treat conditions like claudication and Raynaud’s disease. It works by helping blood flow more easily to your legs and feet.

Contrast mediums: These are substances used in medical imaging to enhance the contrast of structures or fluids within the body.

It’s important to note that while these medications have been reported to cause aphasia, it is a rare side effect. If you or someone else is taking one of these medications and you’re concerned about aphasia, it’s important to discuss these concerns with a healthcare provider. They can provide more information about the risks and benefits of these medications.


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