Can you take paracetamol with Gilbert’s syndrome? Can you take aspirin with Gilbert’s syndrome?

Gilbert’s syndrome is an inherited condition often discovered by accident, such as when someone has a blood test. It occurs due to a defect in the processing of bilirubin by the liver. The syndrome may cause the skin and the whites of the eyes to have a yellow tinge due to the build-up of bilirubin. Gilbert’s syndrome is typically harmless and treatment isn’t required.

Can you take paracetamol with Gilbert’s syndrome?

Despite being safe in therapeutic doses, in high-risk populations, or in excessive amounts it may cause hepatotoxicity. Patients with Gilbert’s syndrome may be more susceptible to the toxic effect of paracetamol, a substance that requires bilirubin-UGT-mediated hepatic glucuronidation before excretion.

Can you take aspirin with Gilbert’s syndrome?

In individuals with Gilbert’s syndrome, there is a buildup of unconjugated bilirubin in the liver as a result of a genetic mutation of the enzyme UDP-glucuronosyltransferase 1A isoform 1 (UGT1A1), which is important in bilirubin metabolism