In the TV series Smallville, Jesse Metcalfe portrayed Van McNulty in the Season 3 episodes “Extinction” and “Asylum”. Metcalfe has acted in “John Tucker Must Die”, “The Other End of The Line”, “God’s Not Dead”, “Fortress”, “The Latin From Manhattan” and “On A Wing And A Prayer”.
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In July 2008, Jesse Metcalfe starred in the horror film Insanitarium portraying the protagonist, Jack. In 2018, Jesse Metcalfe played the role of Luke in the action thriller Escape Plan 2: Hades.
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Jesse Metcalfe played the role of Miguel Lopez-Fitzgerald on the NBC soap opera Passions from the show’s debut in July 1999. In February 2010, Jesse Metcalfe was cast in the NBC crime drama series Chase.
In October 2004, Jesse Metcalfe starred in the ABC comedy-drama series Desperate Housewives as teen gardener John Rowland.
In September 2010, Metcalfe starred as Noah McManus in the Hallmark movie Fairfield Road alongside Natalie Lisinska. Jesse Metcalfe starred as Brady in the horror thriller film The Ninth Passenger.


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