Is Gilbert’s syndrome pre hepatic or hepatic?

Gilbert’s syndrome is an inherited condition often discovered by accident, such as when someone has a blood test. It occurs due to a defect in the processing of bilirubin by the liver. The syndrome may cause the skin and the whites of the eyes to have a yellow tinge due to the build-up of bilirubin. Gilbert’s syndrome is typically harmless and treatment isn’t required.

Is Gilbert’s syndrome pre-hepatic or hepatic?

In a person with Gilbert’s syndrome, the liver is unable to consistently process the yellowish–brown pigment in bile, called bilirubin. This leads to high levels of bilirubin in the bloodstream, which can cause the skin and eyes to turn yellow (jaundice).

Unconjugated bilirubin is insoluble and is not excreted in the urine. It is most commonly due to increased hemolysis—for example, in spherocytosis, homozygous sickle cell disease, or thalassemia major—and patients are often anemic with splenomegaly.