What is a liver function test for Gilbert’s syndrome?

Gilbert’s syndrome is an inherited condition often discovered by accident, such as when someone has a blood test. It occurs due to a defect in the processing of bilirubin by the liver. The syndrome may cause the skin and the whites of the eyes to have a yellow tinge due to the build-up of bilirubin. Gilbert’s syndrome is typically harmless and treatment isn’t required.

What is a liver function test for Gilbert’s syndrome?

The combination of standard blood counts and liver enzymes with an elevated bilirubin level is an indicator of Gilbert syndrome. No other testing usually is needed, although genetic testing can confirm the diagnosis.

People with Gilbert’s syndrome don’t produce enough liver enzymes to keep bilirubin at a normal level. As a result, excess bilirubin builds up in the body. Excess bilirubin is known as hyperbilirubinemia.

An estimated 3% to 7% of Americans have Gilbert’s syndrome. This type of liver disease is more common in males than in females. It affects all ages, races, and ethnicities.