Cushing’s disease is a rare condition that occurs when the body produces too much of the hormone cortisol. This overproduction can be caused by a tumor in the pituitary gland, which is located at the base of the brain. The excess cortisol in the body can lead to a variety of health problems, including weight gain, high blood pressure, diabetes, and depression.
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In recent years, new treatments have been developed for Cushing’s disease. One of these is a medication called Isturisa (osilodrostat). This drug was approved by the U.S. Food and Drug Administration in 2020 for adults with Cushing’s disease who either cannot undergo pituitary gland surgery or have undergone the surgery but still have the disease.
Isturisa works by blocking the enzyme known as 11-beta-hydroxylase, which is involved in the production of cortisol. By blocking this enzyme, Isturisa can prevent the synthesis of cortisol and help to bring cortisol levels back to normal. This can help to alleviate the symptoms of Cushing’s disease and improve the patient’s quality of life.
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In clinical trials, Isturisa was found to be effective in maintaining normal cortisol levels in the majority of patients. In one study, 86% of patients receiving Isturisa maintained cortisol levels within normal limits compared to 30% of patients taking a placebo.
In addition to Isturisa, other new treatments for Cushing’s disease include advanced MRI techniques to find small pituitary tumors, endoscopic transnasal pituitary surgery, stereotactic radiosurgery, and a minimally invasive surgery to remove the adrenal glands (laparoscopic adrenalectomy).
While these new treatments offer hope for patients with Cushing’s disease, it’s important to note that treatment must be individualized for each patient, taking into account their specific circumstances and overall health. Therefore, if you or someone you know has been diagnosed with Cushing’s disease, it’s important to discuss all treatment options with a healthcare provider.
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