Cushing’s disease and Cushing’s syndrome are two related conditions that involve the hormone cortisol. Cushing’s disease is a specific form of Cushing’s syndrome. It is caused by an overproduction of adrenocorticotropic hormone (ACTH) by the pituitary gland.
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The excess ACTH then stimulates the adrenal glands to produce too much cortisol. In medical terms, this condition is often referred to as secondary hypercortisolism or tertiary hypercortisolism. Another scientific name for Cushing’s disease is Itsenko-Cushing disease.
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On the other hand, Cushing’s syndrome is a more general term that refers to any condition characterized by an excess of cortisol in the body. This can be caused by various factors, including long-term use of corticosteroid medications, tumors in the adrenal glands, or, as mentioned above, overproduction of ACTH by the pituitary gland (which is specifically referred to as Cushing’s disease). In the scientific community, Cushing’s syndrome is also known as hypercortisolism or Itsenko-Cushing syndrome.
In summary, while both Cushing’s disease and Cushing’s syndrome involve an excess of cortisol, the terms are used to distinguish between different causes of this hormonal imbalance. Cushing’s disease specifically refers to cases caused by an overactive pituitary gland, while Cushing’s syndrome is a broader term that encompasses all causes of excess cortisol.


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